Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.

Molecular and cellular endocrinology - 15 Oct 2016

Janovick Jo Ann, Spicer Timothy P, Smith Emery, Bannister Thomas D, Kenakin Terry, Scampavia Louis, Conn P Michael

Abstract excerpt

Pharmacoperones rescue misrouted mutants of the vasopressin receptor type 2 (V2R) and enable them to traffic to the correct biological locus where they function. Previously, a library of nearly 645,000 structures was interrogated with a high throughput screen; pharmacoperones were identified for V2R mutants with a view toward correcting the underlying mutational defects in nephrogenic diabetes insipidus. In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HeLa Cells
Share to High-Throughput Screening Assays

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Peptide Library

Share to Protein Folding

Share to Protein Transport

Share to Receptors, Vasopressin

Share to Small Molecule Libraries

Source

Open in PubMed Open full text

Identifiers

PMID: 27389877
DOI: 10.1016/j.mce.2016.07.003
PMCID: PMC4983495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Receptor antagonism/agonism can be uncoupled from pharmacoperone activity.PMID 27389877Read ↗

Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.Semantic proximity Read ↗

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.Semantic proximity Read ↗

Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs.Semantic proximity Read ↗

Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors.Semantic proximity Read ↗

Misfolding of vasopressin receptors: biased agonist pharmacochaperones as potential therapeutics.Semantic proximity Read ↗

Vasopressin receptors and pharmacological chaperones: from functional rescue to promising therapeutic strategies.Semantic proximity Read ↗

Characterization of three vasopressin receptor 2 variants: an apparent polymorphism (V266A) and two loss-of-function mutations (R181C and M311V).Semantic proximity Read ↗

Pharmacoperones as a New Therapeutic Approach: In Vitro Identification and In vivo Validation of Bioactive Molecules.Semantic proximity Read ↗

Analysis of the V2 Vasopressin Receptor (V2R) Mutations Causing Partial Nephrogenic Diabetes Insipidus Highlights a Sustainable Signaling by a Non-peptide V2R Agonist.Semantic proximity Read ↗

Functional rescue of vasopressin V2 receptor mutants in MDCK cells by pharmacochaperones: relevance to therapy of nephrogenic diabetes insipidus.Semantic proximity Read ↗

V2 vasopressin receptor mutations.Semantic proximity Read ↗

Pharmacochaperones post-translationally enhance cell surface expression by increasing conformational stability of wild-type and mutant vasopressin V2 receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.