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Article

Integrative whole-genome sequence analysis reveals roles of regulatory mutations in BCL6 and BCL2 in follicular lymphoma.

Scientific reports - 1 Aug 2017

Batmanov Kirill, Wang Wei, Bjørås Magnar, Delabie Jan, Wang Junbai

Abstract excerpt

The contribution of mutations in regulatory regions to tumorigenesis has been the subject of many recent studies. We propose a new framework for integrative analysis of genome-wide sequencing data by considering diverse genetic information. This approach is applied to study follicular lymphoma (FL), a disease for which little is known about the contribution of regulatory gene mutations. Results from a test FL...

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Topics

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Share to Lymphoma, Follicular
Share to Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-bcl-2

Share to Proto-Oncogene Proteins c-bcl-6

Share to Regulatory Sequences, Nucleic Acid

Share to Sequence Analysis, DNA

Share to Transcription Factors

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 28765546
DOI: 10.1038/s41598-017-07226-4
PMCID: PMC5539289

Genes

BCL2
BCL6
FOXD2
FOXD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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