Article
Mutational, immune microenvironment, and clinicopathological profiles of diffuse large B-cell lymphoma and follicular lymphoma with BCL6 rearrangement.
Virchows Archiv : an international journal of pathology - 1 Apr 2024
Carreras Joaquim, Ikoma Haruka, Kikuti Yara Yukie, Miyaoka Masashi, Hiraiwa Shinichiro, Tomita Sakura, Kondo Yusuke, Ito Atsushi, Nagase Shunsuke, Miura Hisanobu, Kawada Hiroshi, Roncador Giovanna, Campo Elias, Hamoudi Rifat, Nakamura Naoya
Abstract excerpt
BCL6-rearrangement (BCL6-R) is associated with a favorable prognosis of follicular lymphoma (FL), but the mechanism is unknown. We analyzed the clinicopathological, immune microenvironment (immune checkpoint, immuno-oncology markers), and mutational profiles of 10 BCL6-R-positive FL, and 19 BCL6-R-positive diffuse large B-cell lymphoma (DLBCL) cases (both BCL2-R and MYC-R negative). A custom-made panel included...
Topics
- Humans
- Lymphoma, Large B-Cell, Diffuse
- Tumor Microenvironment
- Lymphoma, Follicular
- Proto-Oncogene Proteins c-bcl-6
- Male
- Female
- Middle Aged
- Aged