Article
An immune response network associated with blood lipid levels.
PLoS genetics - 9 Sept 2010
Inouye Michael, Silander Kaisa, Hamalainen Eija, Salomaa Veikko, Harald Kennet, Jousilahti Pekka, Männistö Satu, Eriksson Johan G, Saarela Janna, Ripatti Samuli, Perola Markus, van Ommen Gert-Jan B, Taskinen Marja-Riitta, Palotie Aarno, Dermitzakis Emmanouil T, Peltonen Leena
Abstract excerpt
While recent scans for genetic variation associated with human disease have been immensely successful in uncovering large numbers of loci, far fewer studies have focused on the underlying pathways of disease pathogenesis. Many loci which are associated with disease and complex phenotypes map to non-coding, regulatory regions of the genome, indicating that modulation of gene transcription plays a key role. Thus,...
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