Article
Impaired immune responses and prolonged allograft survival in Sly1 mutant mice.
Molecular and cellular biology - 1 Nov 2005
Beer Sandra, Scheikl Tanja, Reis Bernhard, Hüser Norbert, Pfeffer Klaus, Holzmann Bernhard
Abstract excerpt
Adaptive immunity is crucial for protective host defense and the development of immunological disorders. SLY1 was recently identified as an X-chromosomal SH3 protein that is serine phosphorylated (Ser27) upon B-and T-cell receptor engagement. Here, we demonstrate that SLY1 is localized in the cyt...
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