GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition.

doi:10.1172/JCI93488

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Article

GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition.

The Journal of clinical investigation - 1 Sept 2017

Enane Francis O, Shuen Wai Ho, Gu Xiaorong, Quteba Ebrahem, Przychodzen Bartlomiej, Makishima Hideki, Bodo Juraj, Ng Joanna, Chee Chit Lai, Ba Rebecca, Seng Koh Lip, Lim Janice, Cheong Rachael, Teo Marissa, Hu Zhenbo, Ng Kwok Peng, Maciejewski Jaroslaw, Radivoyevitch Tomas, Chung Alexander, Ooi London Lucien, Tan Yu Meng, Cheow Peng-Chung, Chow Pierce, Chan Chung Yip, Lim Kiat Hon, Yerian Lisa, Hsi Eric, Toh Han Chong, Saunthararajah Yogen

Abstract excerpt

The most frequent chromosomal structural loss in hepatocellular carcinoma (HCC) is of the short arm of chromosome 8 (8p). Genes on the remaining homologous chromosome, however, are not recurrently mutated, and the identity of key 8p tumor-suppressor genes (TSG) is unknown. In this work, analysis of minimal commonly deleted 8p segments to identify candidate TSG implicated GATA4, a master transcription factor...

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Identifiers

PMID: 28758902
DOI: 10.1172/JCI93488
PMCID: PMC5669578

Genes

GATA4
MED12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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