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Article

Potential therapies for anaplastic lymphoma kinase-driven tumors in children: progress to date.

Paediatric drugs - 1 Jun 2013

Lowe Eric J, Lim Megan S

Abstract excerpt

Anaplastic lymphoma kinase (ALK) is an oncogenic tyrosine kinase that is deregulated due to a variety of molecular mechanisms in pediatric cancer. They include chromosomal translocations, activation mutations, and gene amplifications. Since the initial discovery of ALK as an oncogenic tyrosine ki...

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Share to Anaplastic Lymphoma Kinase
Share to Antineoplastic Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphoma, Large B-Cell, Diffuse

Share to Neoplasms

Share to Neuroblastoma

Share to Receptor Protein-Tyrosine Kinases

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23696342
DOI: 10.1007/s40272-013-0027-3
PMCID: PMC4267854

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23696342-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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