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Article

Phenotyping first-generation genome editing mutants: a new standard?

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2017

Teboul Lydia, Murray Stephen A, Nolan Patrick M

Abstract excerpt

The unprecedented efficiency of the CRISPR/Cas9 system in genome engineering has opened the prospect of employing mutant founders for phenotyping cohorts, thus accelerating research projects by circumventing the requirement to generate cohorts using conventional two- or three-generation crosses. However, these first-generation mutants are often genetic mosaics, with a complex and difficult to define genetic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28756587
DOI: 10.1007/s00335-017-9711-x
PMCID: PMC5569115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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