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Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control.

Methods (San Diego, Calif.) - 15 May 2017

Mianné Joffrey, Codner Gemma F, Caulder Adam, Fell Rachel, Hutchison Marie, King Ruairidh, Stewart Michelle E, Wells Sara, Teboul Lydia

Abstract excerpt

The application of CRISPR/Cas9 technology has revolutionised genetics by greatly enhancing the efficacy of genome editing in the early embryo. Furthermore, the system has enabled the generation of allele types previously incompatible with in vivo mutagenesis. Despite its versatility and ease of implementation, CRISPR/Cas9 editing outcome is unpredictable and can generate mosaic founders. Therefore, careful...

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PMID: 28363792
DOI: 10.1016/j.ymeth.2017.03.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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