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Article

Neutralized chimeric DNA probe for detection of single nucleotide polymorphism on surface plasmon resonance biosensor.

Biosensors & bioelectronics - 15 Jan 2018

Huang Chun-Jen, Lin Zhong-En, Yang Yuh-Shyong, Chan Hardy Wai-Hong, Chen Wen-Yih

Abstract excerpt

An implementation of neutralized chimeric DNA oligomer as a probe for sensitive detection of single nucleotide polymorphisms (SNPs) on a surface plasmon resonance imaging sensor is investigated. The chimeric DNA oligomer was synthesized in a conventional DNA synthesizer, containing neutral nucleotides with a methylated phosphate group. The secondary structures and melting points of the chimeric DNA fragment and...

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PMID: 28755610
DOI: 10.1016/j.bios.2017.07.052

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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