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Article

Thioredoxin-interacting protein induced α-synuclein accumulation via inhibition of autophagic flux: Implications for Parkinson's disease.

CNS neuroscience & therapeutics - 1 Sept 2017

Su Cun-Jin, Feng Yu, Liu Teng-Teng, Liu Xu, Bao Jun-Jie, Shi Ai-Ming, Hu Duan-Min, Liu Tong, Yu Yun-Li

Abstract excerpt

AIMS: Thioredoxin-interacting protein (TXNIP) is associated with activation of oxidative stress through inhibition of thioredoxin (Trx). However, some evidences point out that TXNIP acts as a scaffolding protein in signaling complex independent of cellular redox regulation. The autophagy-lysosomal pathway plays important roles in the clearance of misfolded proteins and dysfunctional organelles. Lysosomal...

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Identifiers

PMID: 28755477
DOI: 10.1111/cns.12721
PMCID: PMC6492710

Genes

TXNIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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