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Article

Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity

24 Jul 2015

Abstract excerpt

α-Synuclein inclusion bodies are a pathological hallmark of several neurodegenerative diseases, including Parkinson's disease, and contain aggregated α-synuclein and a variety of recruited factors, including protein chaperones, proteasome components, ubiquitin and the small ubiquitin-like modifier, SUMO-1. Cell culture and animal model studies suggest that misfolded, aggregated α-synuclein is actively...

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PMID: 26213981
DOI: 10.3390/biom5031697

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