Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study.

doi:10.1182/bloodadvances.2020003444

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Article

Genomic analysis of primary and secondary myelofibrosis redefines the prognostic impact of ASXL1 mutations: a FIM study.

Blood advances - 9 Mar 2021

Luque Paz Damien, Riou Jérémie, Verger Emmanuelle, Cassinat Bruno, Chauveau Aurélie, Ianotto Jean-Christophe, Dupriez Brigitte, Boyer Françoise, Renard Maxime, Mansier Olivier, Murati Anne, Rey Jérôme, Etienne Gabriel, Mansat-De Mas Véronique, Tavitian Suzanne, Nibourel Olivier, Girault Stéphane, Le Bris Yannick, Girodon François, Ranta Dana, Chomel Jean-Claude, Cony-Makhoul Pascale, Sujobert Pierre, Robles Margot, Ben Abdelali Raouf, Kosmider Olivier, Cottin Laurane, Roy Lydia, Sloma Ivan, Vacheret Fabienne, Wemeau Mathieu, Mossuz Pascal, Slama Borhane, Cussac Vincent, Denis Guillaume, Walter-Petrich Anouk, Burroni Barbara, Jézéquel Nathalie, Giraudier Stéphane, Lippert Eric, Socié Gérard, Kiladjian Jean-Jacques, Ugo Valérie

Abstract excerpt

We aimed to study the prognostic impact of the mutational landscape in primary and secondary myelofibrosis. The study included 479 patients with myelofibrosis recruited from 24 French Intergroup of Myeloproliferative Neoplasms (FIM) centers. The molecular landscape was studied by high-throughput sequencing of 77 genes. A Bayesian network allowed the identification of genomic groups whose prognostic impact was...

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PMID: 33666653
DOI: 10.1182/bloodadvances.2020003444
PMCID: PMC7948260

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