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Article

Epigenetics in Myeloproliferative Neoplasms.

Journal of cellular and molecular medicine - 1 Sept 2017

McPherson Suzanne, McMullin Mary Frances, Mills Ken

Abstract excerpt

A decade on from the description of JAK2 V617F, the MPNs are circumscribed by an increasingly intricate landscape. There is now evidence that they are likely the result of combined genetic dysregulation, with several mutated genes involved in the regulation of epigenetic mechanisms. Epigenetic changes are not due to a change in the DNA sequence but are reversible modifications that dictate the way in which genes...

Topics

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Chromatin
DNA Methylation
Epigenesis, Genetic
CBL gene
IKZF1 gene
MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myeloproliferative Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 28677265
DOI: 10.1111/jcmm.13095
PMCID: PMC5571538

Genes

JAK2
ASXL1
CALR
CBL
IDH1
IDH2
IKZF1
MPL
TET2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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