Article
A DNA Walker as a Fluorescence Signal Amplifier.
Nano letters - 13 Sept 2017
Wang Dongfang, Vietz Carolin, Schröder Tim, Acuna Guillermo, Lalkens Birka, Tinnefeld Philip
Abstract excerpt
Sensing nucleic acids typically involves the recognition of a specific sequence and reporting by, for example, a fluorogenic reaction yielding one activated dye molecule per detected nucleic acid. Here, we show that after binding to a DNA origami track a bound DNA target (a "DNA walker") can release the fluorescence of many molecules by acting as the catalyst of an enzymatic nicking reaction. As the walking...
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