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Article

The label-free unambiguous detection and symbolic display of single nucleotide polymorphisms on DNA origami.

Nano letters - 9 Feb 2011

Subramanian Hari K K, Chakraborty Banani, Sha Ruojie, Seeman Nadrian C

Abstract excerpt

Single nucleotide polymorphisms (SNPs) are the most common genetic variation in the human genome. Kinetic methods based on branch migration have proved successful for detecting SNPs because a mispair inhibits the progress of branch migration in the direction of the mispair. We have combined the effectiveness of kinetic methods with atomic force microscopy of DNA origami patterns to produce a direct visual readout...

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Share to DNA Mutational Analysis
Share to Microscopy, Atomic Force

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Share to Staining and Labeling

Source

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Identifiers

PMID: 21235216
DOI: 10.1021/nl104555t
PMCID: PMC3036790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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