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Article

Zeptomole Biosensing of DNA with Flexible Selectivity Based on Acoustic Levitation of a Single Microsphere Binding Gold Nanoparticles by Hybridization.

ACS sensors - 28 Sept 2018

Miyagawa Akihisa, Harada Makoto, Okada Tetsuo

Abstract excerpt

A novel scheme for DNA sensing at the zeptomole level is presented, based on the levitation of a single microsphere in a combined acoustic-gravitational (CAG) field. The levitation of a microsphere in the field is predominantly determined by its density. Capture and reporter probe DNAs are anchored on poly(methyl methacrylate) microsphere (PMMA) and gold nanoparticles (AuNPs), respectively, and a target DNA...

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PMID: 30152225
DOI: 10.1021/acssensors.8b00748

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KRAS

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