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Meningococcal Factor H Binding Proteins in Epidemic Strains from Africa: Implications for Vaccine Development

6 Sept 2011

Abstract excerpt

BACKGROUND: Factor H binding protein (fHbp) is an important antigen for vaccines against meningococcal serogroup B disease. The protein binds human factor H (fH), which enables the bacteria to resist serum bactericidal activity. Little is known about the vaccine-potential of fHbp for control of meningococcal epidemics in Africa, which typically are caused by non-group B strains. METHODOLOGY/PRINCIPAL FINDINGS: We...

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PMID: 21909444
DOI: 10.1371/journal.pntd.0001302

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