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Article

Depression and Catechol-O-methyltransferase (COMT) genetic variants are associated with pain in Parkinson's disease.

Scientific reports - 24 Jul 2017

Lin Chin-Hsien, Chaudhuri K Ray, Fan Jun-Yu, Ko Chia-I, Rizos Alexandra, Chang Chia-Wen, Lin Han-I, Wu Yih-Ru

Abstract excerpt

Pain is a distressing symptom of Parkinson disease (PD). We aim to determine whether the genetic variants of chronic pain-related genes contribute to pain in PD patients. We included 418 PD patients and evaluated pain severity on King's PD pain scale. We genotyped rs6267, rs6269, rs4633, rs4818 and rs4680 of COMT, rs6746030 of SCN9A, and of OPRM1. In total, 193 participants (46.2%) experienced pain....

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Share to Catechol O-Methyltransferase
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Share to NAV1.7 Voltage-Gated Sodium Channel
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Share to Receptors, Opioid, mu
Share to Severity of Illness Index

Source

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Identifiers

PMID: 28740224
DOI: 10.1038/s41598-017-06782-z
PMCID: PMC5524945

Genes

COMT
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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