Article
Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure.
Respiratory research - 24 Jul 2017
de Jong K, Vonk J M, Imboden M, Lahousse L, Hofman A, Brusselle G G, Probst-Hensch N M, Postma D S, Boezen H M
Abstract excerpt
BACKGROUND: Studies aiming to assess genetic susceptibility for impaired lung function levels upon exposure to environmental tobacco smoke (ETS) have thus far focused on candidate-genes selected based on a-priori knowledge of potentially relevant biological pathways, such as glutathione S-transferases and ADAM33. By using a hypothesis-free approach, we aimed to identify novel susceptibility loci, and additionally...
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