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Article

Structural determinants of the cellular localization and shuttling of TDP-43

28 Oct 2008

Abstract excerpt

TDP-43 (also known as TARDBP) regulates different processes of gene expression, including transcription and splicing, through RNA and DNA binding. Moreover, recent reports have shown that the protein interacts with the 3'UTRs of specific mRNAs. The aberrant cellular distribution and aggregation of TDP-43 were recently reported in neurodegenerative diseases, namely frontotemporal lobar degeneration (FTLD) and...

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PMID: 18957508
DOI: 10.1242/jcs.038950

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