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Article

Direct targets of pSTAT5 signalling in erythropoiesis

21 Jul 2017

Abstract excerpt

Erythropoietin (EPO) acts through the dimeric erythropoietin receptor to stimulate proliferation, survival, differentiation and enucleation of erythroid progenitor cells. We undertook two complimentary approaches to find EPO-dependent pSTAT5 target genes in murine erythroid cells: RNA-seq of newly transcribed (4sU-labelled) RNA, and ChIP-seq for pSTAT5 30 minutes after EPO stimulation. We found 302...

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PMID: 28732065
DOI: 10.1371/journal.pone.0180922

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