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The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis

17 Mar 2023

Abstract excerpt

Normal erythropoiesis requires the precise regulation of gene expression patterns, and transcription cofactors play a vital role in this process. Deregulation of cofactors has emerged as a key mechanism contributing to erythroid disorders. Through gene expression profiling, we found HES6 as an abundant cofactor expressed at gene level during human erythropoiesis. HES6 physically interacted with GATA1 and...

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PMID: 36929421
DOI: 10.1093/nar/gkad167

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