Article
Integrative view on how erythropoietin signaling controls transcription patterns in erythroid cells.
Current opinion in hematology - 1 May 2018
Perreault Andrea A, Venters Bryan J
Abstract excerpt
PURPOSE OF REVIEW: Erythropoietin (EPO) is necessary and sufficient to trigger dynamic transcriptional patterns that drive the differentiation of erythroid precursor cells into mature, enucleated red cells. Because the molecular cloning and Food and Drug Administration approval for the therapeutic use of EPO over 30 years ago, a detailed understanding of how EPO works has advanced substantially. Yet, the precise...
Topics
- Anemia
- Animals
- Epigenesis, Genetic
- Erythroid Cells
- Erythropoietin
- Humans
- Mutation
- Signal Transduction
- Transcription, Genetic