Article
Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12.
Scientific reports - 20 Jul 2017
De Koker S, Van Hoecke L, De Beuckelaer A, Roose K, Deswarte K, Willart M A, Bogaert P, Naessens T, De Geest B G, Saelens X, Lambrecht B N, Grooten J
Abstract excerpt
Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented at the level of the individual cell, little is however known on the precise identity of the innate immune cells that...
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