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Article

Molecular determinants of acidic pH-dependent transport of human equilibrative nucleoside transporter 3.

The Journal of biological chemistry - 8 Sept 2017

Rahman Md Fazlur, Askwith Candice, Govindarajan Rajgopal

Abstract excerpt

Equilibrative nucleoside transporters (ENTs) translocate hydrophilic nucleosides across cellular membranes and are essential for salvage nucleotide synthesis and purinergic signaling. Unlike the prototypic human ENT members hENT1 and hENT2, which mediate plasma membrane nucleoside transport at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially localized to mitochondria. Recent studies...

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Identifiers

PMID: 28729424
DOI: 10.1074/jbc.M117.787952
PMCID: PMC5592659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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