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Article

Prevalence of germ-line mutations in cancer genes among pancreatic cancer patients with a positive family history.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2018

Chaffee Kari G, Oberg Ann L, McWilliams Robert R, Majithia Neil, Allen Brian A, Kidd John, Singh Nanda, Hartman Anne-Renee, Wenstrup Richard J, Petersen Gloria M

Abstract excerpt

PurposePanel-based genetic testing has identified increasing numbers of patients with pancreatic ductal adenocarcinoma (PDAC) who carry germ-line mutations. However, small sample sizes or number of genes evaluated limit prevalence estimates of these mutations. We estimated prevalence of mutations in PDAC patients with positive family history.MethodsWe sequenced 25 cancer susceptibility genes in lymphocyte DNA...

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Source

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Identifiers

PMID: 28726808
DOI: 10.1038/gim.2017.85
PMCID: PMC5760284

Genes

ATM
BARD1
PMS2
BRCA1
BRCA2
CHEK2
MSH2
MUTYH
NBN
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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