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Article

Cell and small animal models for phenotypic drug discovery.

Drug design, development and therapy - 1 Jan 2017

Szabo Mihaly, Svensson Akusjärvi Sara, Saxena Ankur, Liu Jianping, Chandrasekar Gayathri, Kitambi Satish S

Abstract excerpt

The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative platform for drug discovery. This review provides an overview of the various model systems and technical advances in imaging and image analyses that strengthen the PDD platform. In PDD screens, compounds of therapeutic value are identified based on the phenotypic perturbations produced irrespective of target(s) or mechanism of...

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Identifiers

PMID: 28721015
DOI: 10.2147/DDDT.S129447
PMCID: PMC5500539

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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