Article
Identification of apoB-100 Peptide-Specific CD8+ T Cells in Atherosclerosis.
Journal of the American Heart Association - 15 Jul 2017
Dimayuga Paul C, Zhao Xiaoning, Yano Juliana, Lio Wai Man, Zhou Jianchang, Mihailovic Peter M, Cercek Bojan, Shah Prediman K, Chyu Kuang-Yuh
Abstract excerpt
BACKGROUND: T cells are found in atherosclerotic plaques, with evidence supporting a potential role for CD8+ T cells in atherogenesis. Prior studies provide evidence of low-density lipoprotein and apoB-100 reactive T cells, yet specific epitopes relevant to the disease remain to be defined. The current study was undertaken to identify and characterize endogenous, antigen-specific CD8+ T cells in atherosclerosis....
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