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Article

Pathogenic Autoimmunity in Atherosclerosis Evolves from HSP60-Reactive CD4 + T Cells.

Journal of cardiovascular translational research - 1 Oct 2024

Wang Shixiang, Chen Yongquan, Zhou Danyan, Zhang Jiawei, Guo Guofeng, Chen Youquan

Abstract excerpt

Clinical evidence suggests anti-Hsp60 antibodies could contribute to atherosclerosis (AS) development, with unclear mechanisms. This study aims to explore the role of anti-HSP60-mediated autoimmunity in AS progression. HSP60-MHC tetramers were used to characterize HSP60-specific CD4 + T cells and assess TCR responses in mice. These cells were transplanted into AS mice to examine immune cell differentiation and...

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Source

Identifiers

PMID: 38767798
DOI: 10.1007/s12265-024-10516-8

Genes

CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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