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Article

Influence of SLCO1B1 polymorphism on maintenance therapy for childhood leukemia.

Pediatrics international : official journal of the Japan Pediatric Society - 1 Aug 2015

Suzuki Ryoko, Fukushima Hiroko, Noguchi Emiko, Tsuchida Masahiro, Kiyokawa Nobutaka, Koike Kazutoshi, Ma Enbo, Takahashi Hideto, Kobayashi Chie, Nakajima-Yamaguchi Ryoko, Sakai Aiko, Saito Makoto, Iwabuchi Atsushi, Kato Keisuke, Nakao Tomohei, Yoshimi Ai, Sumazaki Ryo, Fukushima Takashi

Abstract excerpt

BACKGROUND: Management of the adverse effects of chemotherapy is essential to improve outcome of children with leukemia. Some genetic polymorphisms can predict treatment-related toxicity, and be used individually in dose modification of 6-mercaptopurine (6-MP) and methotrexate (MTX) in maintenance therapy for childhood acute lymphoblastic leukemia (ALL). We investigated associations between clinical course and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25939871
DOI: 10.1111/ped.12682

Genes

ITPA
MTHFR
RFC1
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Influence of SLCO1B1 polymorphism on maintenance therapy for childhood leukemia.PMID 25939871Read ↗

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