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Decreased parvalbumin mRNA levels in cerebellar Purkinje cells in autism

14 Jul 2017

Abstract excerpt

Recent neuropathology studies in human brains indicate that several areas of the prefrontal cortex have decreased numbers of parvalbumin interneurons or decreased parvalbumin expression in Autism Spectrum disorders (ASD) [Hashemi, Ariza, Rogers, Noctor, & Martinez-Cerdeno, 2017; Zikopoulos & Barbas, ]. These data suggest that a deficit in parvalbumin may be a key neuropathology of ASD and contribute to altered...

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PMID: 28707805
DOI: 10.1002/aur.1835

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