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Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis

14 Jul 2017

Abstract excerpt

The complement pathway has potential contributions to both white (WM) and grey matter (GM) pathology in Multiple Sclerosis (MS). A quantitative assessment of complement involvement is lacking. Here we describe the use of Tissue MicroArray (TMA) methodology in conjunction with immunohistochemistry to investigate the localization of complement pathway proteins in progressive MS cortical GM and subcortical WM....

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PMID: 28707765
DOI: 10.1111/bpa.12546

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