Article

JOINT APPLICATION OF BRAIN MRI AND GENE EXPRESSION ATLAS TO RECONSTRUCT NMOSD PATHOPHYSIOLOGY

2023-07-23

Abstract excerpt

<h4>Objective</h4> Brain lesions in aquaporin-4-antibody-positive neuromyelitis optica spectrum disorder (AQP4+NMOSD) occur at areas of high AQP4 expression. However, the pathophysiological cascade requires additional factors such as complement. We sought to investigate the spatial association between brain damage and gene expression in AQP4+NMOSD. <h4>Methods</h4> In this multicenter cross-sectional study, we enr...

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Literature Corpus work: 2667baa7-b70f-50d4-bbcb-39a1e62e29ca
DOI: 10.1101/2023.07.19.23292876

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