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Article

Complement Activation Is Associated With Disease Severity in Multiple Sclerosis

14 Feb 2024

Abstract excerpt

Background and Objectives Histopathologic studies have identified immunoglobulin (Ig) deposition and complement activation as contributors of CNS tissue damage in multiple sclerosis (MS). Intrathecal IgM synthesis is associated with higher MS disease activity and severity, and IgM is the strongest complement-activating immunoglobulin. In this study, we investigated whether complement components (CCs) and...

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PMID: 38354323
DOI: 10.1212/nxi.0000000000200212

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