Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.

doi:10.1038/s41598-017-05447-1

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Article

Genotypic variability based association identifies novel non-additive loci DHCR7 and IRF4 in sero-negative rheumatoid arthritis.

Scientific reports - 13 Jul 2017

Wei Wen-Hua, Viatte Sebastien, Merriman Tony R, Barton Anne, Worthington Jane

Abstract excerpt

Sero-negative rheumatoid arthritis (RA) is a highly heterogeneous disorder with only a few additive loci identified to date. We report a genotypic variability-based genome-wide association study (vGWAS) of six cohorts of sero-negative RA recruited in Europe and the US that were genotyped with the Immunochip. A two-stage approach was used: (1) a mixed model to partition dichotomous phenotypes into an additive...

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PMID: 28706201
DOI: 10.1038/s41598-017-05447-1
PMCID: PMC5509675

Genes

DHCR7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.