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Article

Major histocompatibility complex harbors widespread genotypic variability of non-additive risk of rheumatoid arthritis including epistasis.

Scientific reports - 25 Apr 2016

Wei Wen-Hua, Bowes John, Plant Darren, Viatte Sebastien, Yarwood Annie, Massey Jonathan, Worthington Jane, Eyre Stephen

Abstract excerpt

Genotypic variability based genome-wide association studies (vGWASs) can identify potentially interacting loci without prior knowledge of the interacting factors. We report a two-stage approach to make vGWAS applicable to diseases: firstly using a mixed model approach to partition dichotomous phenotypes into additive risk and non-additive environmental residuals on the liability scale and secondly using the...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

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Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Source

Open in PubMed Open full text

Identifiers

PMID: 27109064
DOI: 10.1038/srep25014
PMCID: PMC4842957

Genes

PTPN22
TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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