Article
The causal relationship between immune cells and both seropositive and seronegative rheumatoid arthritis: A bidirectional Mendelian randomization study.
Medicine - 13 Feb 2026
Pan Xiaohan, Xu Shen, Cheng Minghuang, Wu Junjie, Zhang Xiaojun, Jiang Wei, Hao Jie
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic, immune-mediated disease with symmetric polyarticular pain and swelling. It includes seropositive RA, marked by specific antibodies, and seronegative RA, without these antibodies. The relationship between immune cells and both types of RA has not been fully elucidated. Therefore, we conducted a two-sample Mendelian randomization analysis with bidirection to evaluate the...
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