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Changes in H3K79 Methylation During Preimplantation Development in Mice

15 Nov 2007

Abstract excerpt

The gene expression pattern of differentiated oocytes is reprogrammed into that of totipotent preimplantation embryos before and/or after fertilization. To elucidate the mechanisms of genome reprogramming, we investigated histone H3 lysine 79 dimethylation (H3K79me2) and trimethylation (H3K79me3) in oocytes and preimplantation embryos via immunocytochemistry. In somatic cells and oocytes, H3K79me2 was observed...

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PMID: 18003948
DOI: 10.1095/biolreprod.107.063453

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