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Article

KAI1(CD82) is a key molecule to control angiogenesis and switch angiogenic milieu to quiescent state

16 Sept 2021

Abstract excerpt

BACKGROUND: Little is known about endogenous inhibitors of angiogenic growth factors. In this study, we identified a novel endogenous anti-angiogenic factor expressed in pericytes and clarified its underlying mechanism and clinical significance. METHODS: Herein, we found Kai1 knockout mice showed significantly enhanced angiogenesis. Then, we investigated the anti-angiogenic roll of Kai1 in vitro and in vivo....

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PMID: 34530889
DOI: 10.1186/s13045-021-01147-6

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