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Article

Endocardial Fibroelastosis Is Caused by Aberrant Endothelial to Mesenchymal Transition

14 Jan 2015

Abstract excerpt

RATIONALE: Endocardial fibroelastosis (EFE) is a unique form of fibrosis, which forms a de novo subendocardial tissue layer encapsulating the myocardium and stunting its growth, and which is typically associated with congenital heart diseases of heterogeneous origin, such as hypoplastic left heart syndrome. Relevance of EFE was only recently highlighted through the establishment of staged biventricular repair...

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Identifiers

PMID: 25587097
DOI: 10.1161/circresaha.116.305629

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