Article
Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.
Development (Cambridge, England) - 1 May 2013
Chen Hanying, Zhang Wenjun, Sun Xiaoxin, Yoshimoto Momoko, Chen Zhuang, Zhu Wuqiang, Liu Jijia, Shen Yadan, Yong Weidong, Li Deqiang, Zhang Jin, Lin Yang, Li Baiyan, VanDusen Nathan J, Snider Paige, Schwartz Robert J, Conway Simon J, Field Loren J, Yoder Mervin C, Firulli Anthony B, Carlesso Nadia, Towbin Jeffrey A, Shou Weinian
Abstract excerpt
Trabeculation and compaction of the embryonic myocardium are morphogenetic events crucial for the formation and function of the ventricular walls. Fkbp1a (FKBP12) is a ubiquitously expressed cis-trans peptidyl-prolyl isomerase. Fkbp1a-deficient mice develop ventricular hypertrabeculation and noncompaction. To determine the physiological function of Fkbp1a in regulating the intercellular and intracellular...
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