Article

GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy

2025-05-21

Abstract excerpt

<title>Abstract</title> <p> Cerebrospinal fluid (CSF) amyloid beta (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau181) are well accepted markers of Alzheimer’s disease. We performed a GWAS meta-analysis including 18,948 individuals of European and 416 non-European ancestry. We identified 12 genome-wide significant loci across all three biomarkers, eight of them novel. We replicated the association of CS...

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Literature Corpus work: 01c9cc1d-27ea-5e1b-b1f8-524405233bcf
DOI: 10.21203/rs.3.rs-6597595/v1

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