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Article

Whole-genome sequencing reveals the impact of lipid pathway and APOE genotype on brain amyloidosis.

Human molecular genetics - 6 Apr 2025

Patel Maulikkumar, Pottier Cyril, Fan Kang-Hsien, Cetin Arda, Johnson Matthew, Ali Muhammad, Liu Menghan, Gorijala Priyanka, Budde John, Shi Ruyu, Cohen Ann D, Becker James T, Snitz Beth E, Aizenstein Howard, Lopez Oscar L, Morris John C, Kamboh M Ilyas, Cruchaga Carlos

Abstract excerpt

Amyloid-PET imaging tracks the accumulation of amyloid beta (Aβ) deposits in the brain. Amyloid plaques accumulation may begin 10 to 20 years before the individual experiences clinical symptoms associated with Alzheimer's diseases (ad). Recent large-scale genome-wide association studies reported common risk factors associated with brain amyloidosis, suggesting that this endophenotype is driven by genetic...

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Share to Alzheimer Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39927718
DOI: 10.1093/hmg/ddaf017
PMCID: PMC11973900

Genes

APOE
SH3GL1
AP2A2
MFSD12
PITPNM3
SCN7A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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