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Article

Downregulation of CFTR promotes epithelial-to-mesenchymal transition and is associated with poor prognosis of breast cancer.

Biochimica et biophysica acta - 1 Dec 2013

Zhang Jie Ting, Jiang Xiao Hua, Xie Chen, Cheng Hong, Da Dong Jian, Wang Yan, Fok Kin Lam, Zhang Xiao Hu, Sun Ting Ting, Tsang Lai Ling, Chen Hao, Sun Xiao Juan, Chung Yiu Wa, Cai Zhi Ming, Jiang Wen Guo, Chan Hsiao Chang

Abstract excerpt

The epithelial-to-mesenchymal transition (EMT), a process involving the breakdown of cell-cell junctions and loss of epithelial polarity, is closely related to cancer development and metastatic progression. While the cystic fibrosis transmembrane conductance regulator (CFTR), a Cl(-) and HCO3(-)...

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Identifiers

PMID: 23916755
DOI: 10.1016/j.bbamcr.2013.07.021

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23916755-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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