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Pancreatic gene expression during the initiation of acute pancreatitis: identification of EGR-1 as a key regulator

24 Jun 2003

Abstract excerpt

We hypothesized that genes expressed in pancreatic acinar cells during the initiation of acute pancreatitis determine the severity of the disease. Therefore, we utilized microarrays to identify those genes commonly induced in rat pancreatic acinar cells within 1-4 h in two in vivo models, caerulein and taurocholate administration. This strategy yielded 51 known genes representing a complex array of molecules,...

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PMID: 12709512
DOI: 10.1152/physiolgenomics.00174.2002

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