Article
A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway.
Molecular neurodegeneration - 11 Jul 2017
Salašová Alena, Yokota Chika, Potěšil David, Zdráhal Zbyněk, Bryja Vítězslav, Arenas Ernest
Abstract excerpt
BACKGROUND: Autosomal-dominant mutations in the Park8 gene encoding Leucine-rich repeat kinase 2 (LRRK2) have been identified to cause up to 40% of the genetic forms of Parkinson's disease. However, the function and molecular pathways regulated by LRRK2 are largely unknown. It has been shown that LRRK2 serves as a scaffold during activation of WNT/β-catenin signaling via its interaction with the β-catenin...
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