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Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer's Disease Transgenic Mice.

Current Alzheimer research - 1 Jan 2018

Liu Shu-Ying, Lu Shuai, Yu Xiao-Lin, Yang Shi-Gao, Liu Wen, Liu Xiang-Meng, Wang Shao-Wei, Zhu Jie, Ji Mei, Liu Dong-Qun, Zhang Zi-Ping, Liu Rui-Tian

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to its pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reducing Aβ levels and inhibiting Aβ-induced neurotoxicity are feasible therapeutic strategies for AD...

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PMID: 29623840
DOI: 10.2174/1567205015666180404160625

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APP

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