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Article

Multiple modes of Lrp4 function in modulation of Wnt/β-catenin signaling during tooth development

11 Jul 2017

Abstract excerpt

During development and homeostasis, precise control of Wnt/β-catenin signaling is in part achieved by secreted and membrane proteins that negatively control activity of the Wnt co-receptors Lrp5 and Lrp6. Lrp4 is related to Lrp5/6 and is implicated in modulation of Wnt/β-catenin signaling, presumably through its ability to bind to the Wise (Sostdc1)/sclerostin (Sost) family of Wnt antagonists. To gain insights...

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PMID: 28694256
DOI: 10.1242/dev.150680

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