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Article

LRP4 mutations, dental anomalies, and oral exostoses.

International journal of paediatric dentistry - 1 Jul 2024

Kantaputra Piranit, Panichkul Weena, Sillapasorn Parisri, Adisornkanj Ploy, Kitsadayurach Panita, Kaewgaya Massupa, Intachai Worrachet, Olsen Bjorn, Ngamphiw Chumpol, Leethanakul Chidchanok, Jatooratthawichot Peeranat, Ketudat Cairns James R, Tongsima Sissades

Abstract excerpt

BACKGROUND: In order to generate a normal set of teeth, fine-tuning of Wnt/β-catenin signaling is required, in which WNT ligands bind to their inhibitors or WNT inhibitors bind to their co-receptors. Lrp4 regulates the number of teeth and their morphology by modulating Wnt/β-catenin signaling as a Wnt/β-catenin activator or inhibitor, depending on its interactions with the partner proteins, such as Sostdc1 and...

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Exome Sequencing
Child, Preschool
Adaptor Proteins, Signal Transducing
Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

LDL-Receptor Related Proteins

Tooth Abnormalities

Wnt Signaling Pathway

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Identifiers

PMID: 38013205
DOI: 10.1111/ipd.13141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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